Paget's Disease of the Nipple Or Paget's Disease of the Breast ; Causes, symptoms, Diagnosis, treat

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Издатель Apr 14, 2025

Paget's Disease of the Nipple, also known as Paget's Disease of the Breast, is a rare form of breast cancer that primarily affects the nipple and the surrounding areola. Here's a detailed overview:

Key Features
Symptoms:

Red, scaly, or flaky skin on the nipple and areola.

Itching, burning, or tingling sensations.

Crusty or hardened skin resembling eczema.

Nipple discharge, which may be yellowish or bloody.

Flattened or inverted nipple.

A lump in the breast in some cases.

Associated Conditions:

Often linked to underlying ductal carcinoma in situ (DCIS) or invasive breast cancer.

Rarely, it may occur without any associated breast cancer.

Causes
The exact cause is not fully understood, but two main theories exist:

Cancer cells from an underlying tumor travel through the milk ducts to the nipple.

The disease originates in the skin cells of the nipple independently.

Diagnosis
Biopsy: A sample of the nipple or areola tissue is examined for cancer cells.

Imaging Tests: Mammograms, ultrasounds, or MRIs may be used to detect underlying breast cancer.

Treatment
Surgery: Options include mastectomy (removal of the entire breast) or breast-conserving surgery (removal of the affected area).

Radiation Therapy: Often used after breast-conserving surgery.

Systemic Treatments: Such as chemotherapy, hormone therapy, or targeted therapy, depending on the presence of invasive cancer

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