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Nicotinamide has been shown to play an important role in DNA repair from UV damage. It has demonstrated benefits in protecting against nonmelanoma skin cancer and actinic keratoses, precancerous lesions. A study published in the New England Journal of Medicine found that oral nicotinamide at 500 mg twice daily for 12 months led to a reduction of 23% in the rate of new nonmelanoma skin cancers, basal cell carcinoma, and squamous cell carcinoma, development. There was also a noted reduction in the development of actinic keratoses. A study evaluating the impact of nicotinamide on protecting against both UVA and UVB damage on melanocytes, the cells that can form melanoma, found a protective effect in vitro. Talk to your Dermatologist to see if this is right for you.

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